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Threadwielders are dark matter creatures with neutrino 'vision'. Broadly, they were responsible for the creation of the universe, which was designed to be self-unpacking. Madjan was the first Threadwielder to gain minimal sentience after the seeding of the universe, and gradually improved himself until he had enough agency to 'awaken' the rest of the Threadwielders coded into the universe.
They're considered immortal for all intents and purposes, their existence coded into layers of abstraction. The most important element of a Threadwielder - the part that they identify with - are the thoughts and memories of a Threadwielder, which are coded into the sub-structure of the universe. The second layer is their dark matter avatar (occasionally referred to as “true self”) which follows an approximately fractal design and allows them to experience consciousness, a very basic personality, and the ability to wield Thread. The third layer is their baryonic avatar, which has the potential of adding emotions and personality.
The only threat thus far known to threaten the identity layer is Teranyina, simply referred to by many Threadwielders as 'the weapon'.